Six captive office workers are literally chained to their desks by a demented, escaped serial killer; former regional manager Thomas Reddmann (Redd). He assigns his 'human resources' the impossible task of proving his innocence or suffering gruesome consequences.

Set in the last days of a dying logging town, Christian (Schneider) returns to his family home for his father Henry's (Rush) wedding. Reconnecting with his childhood friend Oliver (Leslie) and Oliver's family, wife Charlotte (Otto) and daughter Hedvig (Young), he unearths a long-buried secret. As he tries to right the wrongs of the past, his actions threaten to shatter the lives of those he left behind years before.

In New York, the ambitious Dr. Jack Byron and his associate Gordon Mitchell present the research of his assistant Sam Rogers to the CEO and board of directors of a corporation to sponsor a scientific expedition to Borneo. The objective is to find a flower, Blood Orchid, that flourishes for a couple of weeks every seven years and could be a fountain of youth, prolonging the expectation of life of human beings. They are succeeded and once in Borneo, they realize that it is the raining season and there is no boat available to navigate on the river. They pay US$ 50,000.00 to convince Captain Bill Johnson and his partner Tran to sail to the location. After an accident in a waterfall, the survivors realize that a pack of anacondas have gathered for mating and their nest is nearby the plantation of Blood Orchid, which made them bigger and bigger.